A. Rivkin, Sean P. Ahearn, Stephanie M. Chichetti
Feb 1, 2010
Citations
1
Influential Citations
37
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The development of a novel series of piperazinyl pyrimidines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a screening hit provided a series of potent gamma-secretase modulators with >180-fold in vitro selectivity over inhibition of Notch cleavage.