Kamelia F. Abd El Kader, S. A. E. El Bialy, M. El-Ashmawy
Oct 1, 2012
Citations
0
Influential Citations
3
Citations
Journal
Journal name not available for this finding
Abstract
Abstract Series of 5-substituted arylpyridin-2(1H)-ones and arylpyrimidin-4(3H)-ones were designed and synthesized based on pirfenidone, a compound which shows promising therapeutic effects for treatment of fibrosis. The compounds 1a–c, 2a–c and 3a–c were obtained under mild conditions by arylation of the appropriate heterocyclic amines with arylboronic acids under Chan-Lam-Evans conditions. The synthesis of the useful synthon N-(4-methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-(1H)-pyridin-2-one (4) is also reported. All compounds were characterized by spectral and elemental analysis and structural elucidation by 1H and 13C NMR is discussed herein.