L. Ying, Liu Jichang, Xu Qianqian
2009
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Journal
Chinese journal of veterinary science
Abstract
Danofloxacin mesylate solution and danofloxacin mesylate liposomes were separately administered to the healthy egg chickens by i.v.and p.o.(5 mg/kg),the concentration-time data were fitted to a two-compartment open model after single intravenous administration of the two dosage forms.The main pharmacokinetic parameters were as follows:T1/2α 0.349 6,0.351 8 h;T1/2β 6.411 4,8.193 2 h;AUC3.799 7,5.066 0 mg/(L·h);CLβ1.723 2,1.131 7 L/(kg·h),respectively.The concentration-time data were both described by a one-compartment open model with first-order absorption after single p.o administration of the two dosage forms.The main pharmacokinetic parameters were as follows:T1/2 Kα 0.301 7,0.524 4 h;T1/2K 4.479 2,5.021 7 h;AUC 3.284 4,4.6106 mg/(L·h);Cmax 0.483 8,1.054 8 mg/L;Tp 1.287 3,1.936 2 h;F 86.44%,91.01%,respectively.The results showed there were significant differences in pharmacokinetics of danofloxacin in egg chickens between two dosage forms,compared with the danofloxacin mesylate solution,the plasma half-life was prolonged,the peak concentration was elevated,the maintain time of effective concentration was later,and the P.O.bioavailability increased in the danofloxacin mesylate liposomes.