Wang Hui, Z. Hong, L. Gang
2009
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Quality indicators
Journal
Chinese Journal of Hospital Pharmacy
Abstract
OBJECTIVE To investigate the effect of liensinine(LIE)on platelet aggregation in rats.METHODS Arachidonic acid(AA)and adenosine diphosphate(ADP)were used to induce rat platelet aggregation.Platelet aggregation at 1,3,5 min and the maximum aggregation rate were observed by Born's turbidimetry.RESULTS LIE 4 mg·L-1 and 8 mg·L-1 markedly inhibited the AA and ADP-induced platelet aggregation.The inhibition rates of LIE at 8 mg·L-1 were similar to those of positive control Aspirin.CONCLUSION LIE has inhibitory effect on platelet aggregation induced by AA and ADP in vitro.