S. Ahmed, Ashwini Kumar, V. Mishra
2016
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Abstract
Abstract Multi- l -arginyl-poly- l -aspartic acid, better known as cyanophycin (CPG), is intracellular nitrogen-rich reserve material, generally found in cyanobacteria and heterotrophs. CPG is synthesized non-ribosomally by cyanophycin synthetase, which has two different active sites for incorporation of Arg and Asp. CPG is structurally a polymer consisting of a poly-α-aspartyl backbone linked to arginine residues at its β-carboxyl groups. Commercially, CPG can be hydrolyzed to produce arginine or poly-aspartates, thereby could serve as an alternative to costly chemical processes. L-Arginine is precursor of biologically important molecules like urea, nitric oxide, citrulline, etc. Arginine is experimentally used for preparation of cationic hydrogels, nutraceuticals, as antimicrobials, and most recently as a therapeutic composition for dentin deposition in case of dental sensitivity. Polyaspartate is a platform chemical for synthesis of (S)-2-Aminotetralins (ATs), used in Parkinson’s disease, etc.