M. keeri-Szanto, J. Pomeroy
May 8, 1971
Citations
0
Influential Citations
55
Citations
Quality indicators
Journal
Lancet
Abstract
Abstract Study of the use of pentazocine for the supplementation of nitrous-oxide relaxant anaesthesia in forty-one patients revealed that a significant correlation exists between high drug requirements and urban living as well as smoking. The excess drug requirement resided in the need for higher maintenance doses rather than in different priming doses for the subgroups. Changes in the rate of pentazocine disposal have been tentatively linked with ambient or self-induced atmospheric pollution, and it is suggested that similar differences are likely to occur with other drugs and in other therapeutic settings.