Stefan Rubner, S. Schubert, T. Berg
Mar 20, 2019
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Influential Citations
8
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Journal
Organic & biomolecular chemistry
Abstract
We report the hydrophobically-tagged Plk1 PBD inhibitor Poloxin-2HT+, which selectively degrades the tumor target Plk1 and induces apoptosis in human tumor cells with higher potency than the hydrophobically-tagged inhibitor Poloxin-2HT. Our data provide further evidence that hydrophobically tagged inhibitors of protein-protein interactions can target and destroy disease-relevant proteins.