M. Carenza, P. Caliceti, F. Veronese
Mar 1, 2000
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Journal
Radiation Physics and Chemistry
Abstract
Abstract Thermosensitive hydrogels were obtained by radiation-induced polymerization of acryloyl- l -proline methyl ester in the presence of a crosslinking agent. The measurements of equilibrium water content in the temperature range between 0° and 60°C showed that the samples swelled at low temperatures while they shrank at high temperatures. These hydrogels were used as drug delivery systems for the controlled release of insulin. In vivo studies carried out on diabetic rats ascertained a significant reduction in the hyperglycemic level in the blood which continued for about 2 months.