C. Sweeley, J. O 'connor, L. Bieber
Oct 1, 1970
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Chemico-biological interactions
Abstract
The polyene macrolides, filipin and flavofungin, have larvicidal activity when added to the diet of Musca domestica larvae. Filipin also prevents the uptake of dietary 14C-labeled cholesterol into the hemolymph of Galleria mellonella larvae. Filipin, but not amphotericin, prevents ovarian development and reproduction of adult houseflies. These findings suggest that the larvicidal and chemosterilant activities of filipin are due to the formation of a complex of filipin and cholesterol which prevent the uptake and utilization of sufficient dietary cholesterol for vital processes. It is proposed that selected polyene macrolides may have potential as control agents for some insect populations by limiting sterol availability.