S. Rossi, M. Benaglia, M. Ortenzi
Dec 7, 2011
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Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Readily available, low cost, hydrosoluble poly(ethylene-glycol) derivatives of 2-(trifluoromethyl)-3,3,3-trifluoro-propanoic acid were easily synthesized and their properties as MRI agents are preliminarily investigated. Two novel polymers, of 2356 Da and 756 Da, respectively, both showing a single 19F signal at NMR in deuterated chloroform and D2O were fully characterized; both compounds were shown to be soluble in water. However when experiments of in vitro MR imaging were conducted a clear imaging was obtained only with the sample of 756 MW, pointing at the importance of the fluorine content of the carrier.