A. V. Erkin, V. Krutikov
Mar 1, 2006
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Journal
Russian Journal of General Chemistry
Abstract
High regioselectivity in the methylation of 2-(2-hydroxyethylamino)-6-methylpyrimidin-4-(3H)-one at the N3 atom in water and ethanol in the presence of inorganic bases is determined by participation of the oxygen atom in hydrogen bonding and its coordination to metal cation, respectively. In going to aprotic dimethylformamide which is capable of solvating cations, the regioselectivity decreases, and a mixture of N3-and O-methyl isomers is formed.