S. Krajcovicova, J. Hlaváč, Kristýna Vychodilová
Mar 1, 2021
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Influential Citations
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Journal
RSC Advances
Abstract
Fast and simple access to N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines is presented. N-Alkylated anthranilic acid derivatives represent important intermediates. They can be advantageously prepared by solid-phase synthesis, by Buchwald–Hartwig amination or reductive amination with wide substrate scope and with excellent crude purities.