P. Ballesteros, Carmen Ubide-Barreda, M. L. Rojas
Feb 12, 2011
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Journal
Arkivoc
Abstract
The polymorphism of racemic imidazol-1ylsuccinic acid derivatives, a series of compounds previously used as extracellular pH probes for NMR spectroscopy, is investigated by crystallization in different solvents. The mono-ester, (±)-3-(ethoxycarbonyl)-2-(imidazol-1-yl) propionic acid, shows two different polymorphs when recrystallized in absolute ethanol (Form I) or water (Form II), respectively. These two forms have been characterized by optical microscopy, powder X-ray diffraction analysis, and thermogravimetry. Polymorphs I and II can also be distinguished by solid state CP-MAS C NMR spectroscopy.