G. Wilkinson, F. Guengerich, R. Branch
1989
Citations
6
Influential Citations
317
Citations
Quality indicators
Journal
Pharmacology & therapeutics
Abstract
This review describes the pharmacological, biochemical and clinical studies that have led to a functional characterization of the mephenytoin polymorphism. In addition, attempts to understand the genetic basis of the metabolic defect at the biochemical and molecular levels are also described