Chun-Lan Yang, Chang-cheng Sheng, Guiyi Liao
Jul 26, 2021
Citations
3
Influential Citations
6
Citations
Quality indicators
Journal
Journal of Clinical Pharmacy and Therapeutics
Abstract
Mycophenolate mofetil, an ester prodrug of mycophenolic acid (MPA), is widely used to prevent graft rejection after kidney transplantation. The pharmacokinetic (PK) of MPA has been extensively studied, which revealed a high degree of variability. An integrated population PK (PopPK) model of MPA and its main metabolite mycophenolic acid glucuronide (MPAG) was developed using the adult patients who underwent kidney transplant and were administered oral mycophenolate mofetil combined with tacrolimus.