U. Okamoto, Y. Nagamatsu, Y. Tsuda
Nov 17, 1980
Citations
0
Influential Citations
11
Citations
Journal
Biochemical and biophysical research communications
Abstract
Summary In a search for an adequate synthetic substrate for human spleen fibrinolytic proteinase (SFP), Suc-Tyr-Leu-Val-pNA was newly synthesized. Its degradation by SFP was compared with that of other synthetic polypeptide substrates. Suc-Tyr-Leu-Val-pNA was degraded by SFP with a high K cat /K m , but it was not degraded by the following serine proteinases, plasmin, trypsin, thrombin, chymotrypsin, urokinase and milk plasminogen-activator, or by pancreatic elastase to any practical extent.