Bing Chen, Hao‐Qiang Shi, Xu Liu
Dec 1, 2017
Citations
1
Influential Citations
19
Citations
Quality indicators
Journal
Journal of Clinical Pharmacy and Therapeutics
Abstract
Tacrolimus (TAC) is widely used as part of immunosuppressive regimens. There is great interindividual variation on the disposition of TAC. The aim of this study was to develop a population pharmacokinetic (PPK) model for Chinese liver transplant patients and evaluate genetic polymorphism and other possible factors on the PK parameters. The exposure of TAC is to be estimated through Bayesian modelling.