Denis Escande, Dominique Thuringer, Sylvain Leguern
Jul 29, 1988
Citations
4
Influential Citations
188
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes.