J. Bin, Jae Sang Lee, K. Kim
Oct 16, 2004
Citations
0
Influential Citations
12
Citations
Journal
Organic letters
Abstract
Treatment of a solution of a mixture of 1-aryl-2-arylsulfonylethanones 9 and alkylsulfonyl chlorides (1.5-2.0 equiv) in THF at 0 degree C with potassium hydroxide (8 equiv) for 10 min gave a rearrangement product, i.e., 1-aryl-2-(arylsulfonylmethanesulfonyl)ethanones 8, in excellent yields. Regiospecific methyl- and ethylation at the methylene carbon sandwiched between two sulfonyl groups of 8 could be achieved by the reactions of 7i-j with LDA (1 equiv) in THF at room temperature, respectively.