C. Hall, O. Hall
Feb 1, 1953
Citations
0
Influential Citations
5
Citations
Journal
Endocrinology
Abstract
OF THE 11-desoxycorticoids which are available for therapeutic use, desoxycorticosterone acetate (DC-acetate) has enjoyed the widest acceptance. In an effort to increase the activity of the hormone either by conferring upon the steroid a more favorable absorption rate or reducing the rate at which it is metabolized by the body, various esters, in addition to the commonly used acetate, have been prepared. The water soluble DC-glucoside has proven to be very effective, when administered intravenously, in effecting the recovery of adrenalectomized dogs from the symptoms of acute adrenal insufficiency (Meier et al., 1944; Swingle et al., 1952). DC-benzoate, DC-palmitate and DC-butyrate have each been found, when given in identical dosage by single injections, to prolong the life of adrenalectomized rats more effectively than either dexoxycorticosterone or its acetate. With the recent preparation of DC-trimethylacetate and DC-phenylacetate, attention has again been focused on the metabolic effects of desoxycor...