U. Girreser
Sep 1, 1999
Citations
0
Influential Citations
9
Citations
Journal
Synthesis
Abstract
The condensation of 1-aryl-2-dimethylaminomethylprop-2-en-1-ones 6 with amidines 9 gives rise to the 5-benzoyl1,4,5,6-tetrahydropyrimidines 11 and the corresponding hydrochorides 5. The reaction is initiated by addition of the more nucleophilic amidine amino group to the enone double bond, followed by deamination and ring closure to give the tetrahydropyrimidine ring system, which may be a remarkable precursor for versatile synthetic studies of pharmacologically active compounds.