W. Gao, D. Johns, H. Mitsuya
Jan 1, 2000
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Influential Citations
23
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Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract Low levels of the CTP synthase inhibitor 3-deazauridine (3-DU) strongly potentiated the anti-HIV-1 activity of the 5′-triphosphates of the cytidine-based analogues [-]2′-deoxy-3′-thiacytidine (3TC; lamivudine) and 2′,3′-dideoxycytidine (ddC). The potentiation was associated with a 3-DU-induced decrease in dCTP pool size; no changes were seen in cellular pool sizes of dATP, dGTP or dTTP.