Thaїs Cailleau, Lauren Adams, Neha Arora
2019
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0
Influential Citations
6
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Journal
Current topics in medicinal chemistry
Abstract
Pyrrolobenzodiazepine (PBD) dimers are highly potent DNA cross linking agents used as warheads in Antibody Drug Conjugates (ADCs) for cancer therapy. We propose to investigate the correlation existing between the lipophilicity of those molecules and their activity (both in vitro and in vivo) as well as any effect observed during conjugation.