Alexander H. Glassman, Stanley R. Platman
Dec 1, 1969
Citations
2
Influential Citations
160
Citations
Quality indicators
Journal
Journal of psychiatric research
Abstract
Abstract This double blind study investigated the reported potentiation of an MAO inhibitor by tryptophan. Twenty seriously depressed patients were placed on phenelzine sulfate. Half of these patients received supplements of tryptophan while the remainder received a placebo. Those receiving the tryptophan supplements showed significantly more improvement as measured by a modified version of the Hamilton scale. The possible pathways for the mediation of this tryptophan effect are discussed.