M. Laverick, A. Nias
Jun 1, 1981
Citations
0
Influential Citations
19
Citations
Journal
The British journal of radiology
Abstract
Previous studies have shown that certain platinum coordination complexes can act as radiosensitizers in vitro and in vivo. Cis-dichlorodiamine-platinum II (cis-PDD), a potent antitumour agent now used in the clinic, acts as a radiosensitizer in both mammalian and bacterial systems (Richmond et al., 1977; Douple and Richmond, 1978). Another platinum II complex, cis-dichlorobis (cyclopentylamine) platinum II (cis-PAD), potentiates damage due to X rays in well oxygenated Chinese hamster ovary (CHO) cells (Szumiel and Nias, 1976) and similar results were reported in a preliminary form for the platinum IV complex CHIP (Nias and Szumiel, 1977). CHIP (see structure in Fig. 1) is one of eight platinum complexes selected from over 300 derivatives of cis-PDD as a possible second generation compound to follow cis-PDD into the clinic (Wilkinson et al., 1978). CHIP is very soluble in aqueous solution and has a good therapeutic index (TI) of 12 as measured by Connors et al. (1971) (cf. cis-PDD with a TI of 8). This kno...