Yingguang Zhu, Hong-Zhu Kan, Liqin Jiang
Apr 15, 2012
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Influential Citations
4
Citations
Journal
Synthetic Communications
Abstract
Abstract A practical and scalable synthesis of ethyl (R)-piperidine-3-acetate was achieved from commercially available 3-pyridylacetic acid in 76% overall yield. The practical synthesis was demonstrated on 100-g scale. One-pot reductive N-ethylation of the pyridinium salt with acetonitrile gave an N-ethyl piperidine derivative. GRAPHICAL ABSTRACT