Bo-Liang Deng, J. Lepoivre, G. Lemiére
Jun 1, 1998
Citations
0
Influential Citations
4
Citations
Journal
European Journal of Organic Chemistry
Abstract
Some 3-methoxyflavones were known to possess antipicornavirus properties. In order to study the structure-activity relationship, attempts to prepare 3-methoxyflavone by literature methods were unsuccessful. We have modified the Baker-Venkataraman rearrangement, using a solid base and a phase-transfer catalyst. After searching optimal reaction conditions and a study of the intermediate formed in a model reaction, good yields were obtained for the 3-methoxyflavones 7, 21–32. Further some of the corresponding 7-O-n-butyl derivatives 4, 33–37 could be isolated as side products.