H. Söling, A. Seck
Mar 1, 1975
Citations
0
Influential Citations
9
Citations
Journal
FEBS Letters
Abstract
Blood glucose lowering sulfonamides do not only stimulate the release of insulin from the P-cell of the pancreas but have also extra-pancreatic effects. One of these effects is the inhibition of hepatic ketogenesis [l-3]. During recent studies of a new hypoglycemic sulfonylurea we observed not only an inhibition of ketogenesis but also of hepatic glucogeneogenesis. We present now data which show that glisoxepide, a new blood glucose lowering sulfonylurea, inhibits in rat liver specifically gluconeogenesis from L-lactate and L-alanine but not from pyruvate. Urea production from endogenous precursors as well as from L-alanine is likewise diminished. Gluconeogenesis from L-lactate is only slightly inhibited in pigeon liver. In isolated rat liver mitochondria glisoxepide inhibits specifically the L-aspartate/L-glutamate exchange.