C. Borchgrevink, R. Andersen, J. Hall
Dec 3, 1960
Citations
0
Influential Citations
20
Citations
Journal
British Medical Journal
Abstract
"Premarin5" is a complex of oestrogen sulphates prepared from the urine of pregnant mares. During recent years it has been widely used as a haemostatic agent mainly in controlling epistaxis, but also in surgery, particularly on the prostatic gland. Jacobson (1941) introduced the term "spontaneous bleeding," by which he understood any bleeding without a known cause such as trauma, surgery, tumours, ulcers, haemorrhagic diathesis, and so on. He believed this kind of bleeding to be a clinical entity, which was caused by a low oestrogen level in the blood, and postulated that premarin might arrest such bleeding. The experimental support for the use of premarin as a haemostatic agent was offered by Johnson (1957). He injected premarin into 12 dogs, and 15 to 30 minutes later he found an increase in prothrombin and proaccelerin (factor V), and a decrease of antithrombin. The effect lasted for several hours. He concluded that