W. Mahabusarakam, K. Kuaha, P. Wilairat
May 1, 2006
Citations
1
Influential Citations
80
Citations
Quality indicators
Journal
Planta medica
Abstract
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.