P. M. Kushakova, A. Chernobroviy, V. А. Kuznetsov
Dec 1, 2004
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The selectivity of the formation of N-di(2-chloroethyl)methylamine in reactions with various chlorinating agents has been investigated and the optimum chlorinating agent has been found. 1-Amino-4-methylpiperazine has been obtained for the first time by the cyclization of N-di(2-chloroethyl)methylamine with aqueous hydrazine. A possible mechanism has been proposed for the cyclization reaction.