A. Katritzky, Qiuhe Long, H. He
Dec 4, 2000
Citations
0
Influential Citations
8
Citations
Journal
Arkivoc
Abstract
Direct O-alkylation of 2-hydroxy-5-methoxybenzaldehyde (1) with alkyl bromides or iodides gave nine 2-alkoxy-5-methoxybenzaldehydes 2a-i in high yields, six of which are novel compounds. Treatment of 2-ethoxy-5-bromobenzaldehydes (3) with n-BuLi, morpholine and nitrobenzene afforded 2-ethoxy-5-hydroxybenzaldehyde (4), which easily underwent Oalkylation to furnish 2-ethoxy-5-alkoxybenzaldehydes 5a-b in total moderate yields.