Li Ma-li
2007
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Journal
Technology & Development of Chemical Industry
Abstract
Two feasible methods,reduction with ion powder(Ⅰ) and catalytic hydrogenation(Ⅱ) were studied to synthesize the intermediate(2-Amino-5-fluorophenol) of indicator 5F-APTRA-AM which could combined with Mg2+.The product quality and yield of scheme(Ⅱ) was better than the scheme(Ⅰ).The synthesis conditions,influence factors and the impurity genesis of 2-Amino-5-fluorophenol of these two methods were also discussed.