Jia Yun-hong
2010
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Journal
Fine Chemical Intermediates
Abstract
The synthesis of 2-methyl-2-phenyl-propan-1-ol by the reaction of 2-chloromethyl-2-phenylpropane and sodium hydroxide in the presence of tetrabutylammonium bromide was studied.The effects of the reaction temperature,the reaction time,the concentration of sodium hydroxide and amount of catalyst on the process were investigated,and the target compound was obtained in 68.7% yield under optimized reaction conditions(70℃,4 h,NaOH concentration 20%,catalyst load 3%).