M. Riaz, Ivanna Pohorilets, Jackson J. Hernandez
Jul 1, 2018
Citations
0
Influential Citations
0
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A practical, operationally simple preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives is described. The cobalt catalyzed coupling of a protected vinyl halide with trimethylsilylmethylmagnesium chloride shows excellent functional group tolerance and provides these synthetically useful allyl silanes in good overall yield. By this method, the use of highly concentrated organolithium reagents, complex reaction protocols, and expensive starting materials is avoided.