D. Pletcher, M. Razaq
Sep 1, 1980
Citations
0
Influential Citations
13
Citations
Journal
Journal of Applied Electrochemistry
Abstract
The electrochemical reduction of 2,3,5-tribromothiophen to 3-bromothiophen may be carried out in good yield with a high current efficiency using a lead, mercury, zinc or graphite cathode in 70% dioxan/30% water containing sodium bromide (0.2 M) and a potential just positive to that for hydrogen evolution. The electrolysis may be designed to form free bromine at the anode or thiophen may be brominated in the anolyte; the product is 2-bromothiophen or 2,5-dibromothiophen which is resistant to further substitution in this solvent. Various strategies for the scale up of this synthesis are discussed.