Liu Zao
2005
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Journal
Chinese Journal of Pharmaceuticals
Abstract
4-(2-Bromoacetyl)-3-fluorophenylboronic acid was synthesized from 4-bromo-2-fluorobenzonitrile b Grignard reaction, protection of carbonyl with ethanediol, Grignard reaction and substitution by borono group to give 4 acetyl-3-fluorophenylboric acid followed by bromination with an overall yield of 54%.