Ma Hai-rong
2013
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Journal
Journal of Zhengzhou Normal Education
Abstract
4,6-Dimethoxy-2-(methylsulfonyl) pyrimidine was synthesized by the methylation and oxidation via environment-friendly processes.The first step was methylation.4,6-Dimethoxy-2-(methylthio)pyrimidine was synthesized from 4,6-dimethoxy-2-mercaptopyrimidine and dimethyl carbonate(DMC) in the presence of Bu4NBr and K2CO3.The second step was oxidation.4,6-Dimethoxy-2-(methylsulfonyl) pyrimidine was synthesized in the presence of H2O2 and Na2WO4·2H2O.Toxic chemical reagent was avoided in these processes.