Li Gao-feng
2010
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Journal
Chemistry World
Abstract
A four-step process for preparing 4-(methylthio) phenylacetonitrile introduced.Firsfly,p-chlorobenzaldehyde reacted with methyl mercaptan sodium in toluene solution to form p-methyl mercaptobenzaldehyde.Secondly,pmethyl mercaptobenzaldehyde was reduced with sodium borohydride into 4-(methylthio) benzyl alcohol.Thirdly,4-(methylthio) benzyl alcohol was converted with hydrochloric acid into 4-(methylthio) benzyl chloride.Finally,4-(methylthio) benzyl chloride was converted with sodium cyanide in the solution of DMSO into 4-(methythio) phenylacetonitrile.The structure of product was indentified by()~1H NMR spectroscopy.The total yield was above 73.9%.