S. Ebdrup, M. S. Jensen, P. Vedsø
1998
Citations
0
Influential Citations
2
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Under appropriate reaction conditions 10-ethylphenothiazine 1 undergoes lithiation at C-4 using an excess of sec-butyllithium–N,N,N′,N′-tetramethylethane-1,2-diamine in diethyl ether. Reaction of the lithiated intermediate with a variety of carbon, halogen, sulfur and silicon electrophiles affords several new 4-substituted 10-ethylphenothiazines 3a–i in good yields.