D. Neumann, B. Jursic, K. Martin
Feb 25, 2002
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A very inexpensive, simple, and high yield procedure for the preparation of valuable pharmaceutical intermediates, 5-cyclohexylmethylbarbiturates, was developed starting from either p -hydroxy or p -methoxybenzaldehyde and barbituric acid. Although the reaction sequence involves several steps, such as selecting a suitable catalyst (5% PdC in 2% percent molar ratio) and solvent (methanol–hydrochloric acid 1:1) the preparation can be carried out in only one practical step (one-pot preparation).