Y. Hai, Liao Wen-wen
2006
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
6-Amino-7-fluoro-2H-1,4-benzoxazin-3(4H)-one(Ⅱ),an essential intermediate for synthesis of herbicide flumioxazin,was prepared through hydrogenation of 7-fluoro-6-nitro-2H-1,4-benzoxazin-3(4H)-one(Ⅰ) catalyzed by Raney Ni with high yield.The optimum process conditions were reaction temperature 80 ℃,reaction time 5 h,amount of catalyst 5% based on Ⅰ,and H_2 pressure 6 MPa.The yield was 95.2% and weight percent of Ⅱ was 98.5%.The solvent and the catalyst were reused for five times and showed no bad effect to the yield and weight percent of the product.The structure of Ⅱ was comfirmed by elementary analysis,IR and ~1HNMR.