Jacqueline E. Milne, K. Jarowicki, P. Kocieňski
Mar 1, 2002
Citations
0
Influential Citations
9
Citations
Journal
Synlett
Abstract
The enol triflate derivatives prepared from readily accessible tetrahydropyran-2-ones undergo Ni(0)-catalysed substitution with LiBr to give the corresponding 6-bromo-3,4-dihydro-2H-pyr-ans under mild conditions. The 6-bromo-3,4-dihydro-2H-pyrans undergo halogen-metal exchange with tert-butyllithium to give the corresponding 6-lithio-3,4-dihydro-2H-pyrans.