J. Pulicani, H. Bouchard, J. Bourzat
Dec 26, 1994
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
The electrochemical reduction of 7α-iodo docetaxel at E-1.3V vs. SCE in methanol in the presence of lithium chloride and hydrochloric acid leads predominantly to 7-deoxy-docetaxel 9. When the electroreduction is conducted at E-1.7V vs. SCE in the presence of sodium acetate and acetic acid, the cyclopropanol-containing taxoid 10 is formed in good yield. Electrochemical reduction of 7-deoxy-docetaxel at C-10 is also reported. All these docetaxel analogs retain biological activity.