D. N. Danil'chuk, B. A. Yankovskii, A. A. Ryzhikov
May 1, 1986
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Journal
Chemistry of Natural Compounds
Abstract
Many years' experience of working on the separation of a mixture of anahasine and lupinine by nitrosation have revealed serious defects of this method, which impelled us to investigate other methods for separating anabasine and lupinine. In the first place, we turned our attention to the fact that in a number of cases it is possible successfully to separate anabasine from the mixture via its hydrochloride. We have studied the solubility of the hydrochlorides of anabasine and of lupinine under various conditions. The results show that the use of the hydrochloride method is limited and is desirable only for a mixture of anabasine and lupinine containing not more than 15-18% of the latter components. The fluosilicate method [6] proved to be the most suitable one. On the basis of the results of the investigations performed and semiindustrial trials, we have proposed a simpler and more rational scheme for the production of AHC.