Rekha Khairwar, D. Mishra, Arun K. Singh
2021
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0
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Journal
Rasayan Journal of chemistry
Abstract
The imidazole derivate say 2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetohydrazide (1) was synthesized. Various Schiff bases (3a-e) of (1) were prepared by reacting with various benzaldehyde derivates (2a-e). All the 3a-e compounds reacted with Succinic Anhydride to afford 1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio) acetamido)-5oxo-2-arylpyrrolidine-3-carboxylic acid derivatives (4a-e). These (4a-e) compounds reacted with o-phenylene diamine yields N-(3-(1H-benzo[d]imidazol-2-yl)-5-oxo-2-arylpyrrolidin-1-yl)-2-(1-methyl-1H-benzo[d]imidazol-2ylthio) acetamide (5a-e). The Compounds (5a-e) reacted with benzaldehyde affords 4-benzylidene derivates(6ae),they further reacted with hydrazine hydrate gives N-(4-(1H-benzo[d]imidazol-2-yl)-5-aryl-3-phenyl-4,5dihydropyrrolo[2,3-c]pyrazol-6(2H)-yl)-2-((1-methyl-1H-benzo[d]imidazol-2-yl)thio)acetamide (7a-e).All the synthesized compounds characterized spectroscopically and tested for antimicrobial activity.