Pranay Shah, R. Patel, P. Vyas
Apr 2, 2019
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Journal
International Journal of Trend in Scientific Research and Development
Abstract
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/ by/4.0) ABSTRACT The Pyrimidone derivatives say, N'-arylidine-6-methyl-2-oxo-4-phenyl-1,2,3, 4tetrahydropyrimidonecarbohydrazides (2a-e) were synthesized by condensation of Benzaldehyde derivatives with 6-Methyl-2-oxo-4-phenyl1,2,3,4-tetrahydro pyrimidone carbohydrazides (1) in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1-[6-methyl2-oxo-4-phenyl-1,2,3, 4-tetrahydropyrimidone-5-carboxamido)-5-oxo-2-aryl pyrrolidine-3-carboxylic acid (3a-e). These (3a-e) on Mannich reaction with formaldehyde and morpholine offered 2-aryl-1-(6-methyl-2-oxo-4-phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamido)-4-(morpholinomethyl)-5oxopyrrolidine-3-carboxylic acid (4a-e). Further (4a-e) on condensation with 1, 2-benzenediamine yield N-(3-(1H-benzo[d]imidazol-2-yl)-2-aryl-4(morpholinomethyl)-5-oxopyrro lidin-1-yl)-6-methyl-2-oxo-4-phenyl-1, 2, 3, 4tetrahydropyrimidine-5-carboxamide (5a-e). Their structures were confirmed by elemental contents and spectral features. The antimicrobial activities of all three series have also been evaluated. The whole synthetic route is shown below.