K. Mehta
Apr 28, 2016
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Quality indicators
Journal
Silpakorn University Science and Technology Journal
Abstract
This research paper describes a study about synthesis, structure determination and antibacterial activity evaluation of some novel heterocyclic compounds having 2-[5-(4-chlorophenyl)-4,5-dihydro-1,2-oxazol-3-yl] fragment. To prepare this kind of compounds, 3-(4-chlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one was prepared. Its coupling reaction was carried out with diazonium salt of 1o aromatic amine. The coupled product was separated and reacted with hydroxylamine hydrochloride. The final product containing 2-[5-(4-chlorophenyl)-4,5-dihydro-1,2-oxazol-3-yl] fragment was characterized with the help of melting point determination and elemental analysis of carbon, hydrogen, nitrogen and chlorine elements. Further characterization was performed with the help of IR, 1H NMR and Mass spectroscopic methods. The characterization study supports the projected structures of heterocyclic derivatives. Antibacterial assay in vitro for these compounds was carried out for Pseudomonas aeruginosa, Bacillus subtilis, Erwinia carotovora and Escherichia coli. It showed good antibacterial activity.