H. Bi
2014
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Journal
Chemistry World
Abstract
4-Bromo-2-(bromomethyl)-1-((4-chlorobenzyl)oxy)benzene(3)was synthesized from 1-chloro-4-(chloromethyl)benzene and 5-bromo-2-hydroxybenzaldehyde by elimination reaction,reduction reaction and bromization.N-Allyl-4-chloro-N-(piperidin-4-yl)benzamide(7)was prepared from piperidin-4-one.Further reaction of(3)with(7)gave a novel non-peptide CCR5antagonist(N-allyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piperidin-4-yl)-4-chlorobenzamide(8).The structure of the product was characterized by 1 H NMR,13 C NMR and MS.