Wang Liguo
2009
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Journal
Fine chemicals
Abstract
2-Amino alkyl benzimidazoles are very important compounds of the benzimidazole derivatives widely used in peptides and pharmaceuticals.2-Aminomethylbenzimidazole was prepared by using o-phenylene diamine(OPD) and glycine as main materials.The target product was characterized by using IR,elementary analysis and melting point.The optimal reaction conditions were:n(OPD)∶n(glycine)=1∶3.5,n(phosphoric acid)∶n(polyphosphoric acid)=1∶2 as catalyst and at the same time as reaction solvent,reaction time 30 h and reaction temperature 190 ℃.The reaction proceeded under the protection of nitrogen.The yield can reach 85%.The novelty of the research work reported by this paper was confirmed by the official report(No.JN280255) issued by the Scientific and Technological Information Institute of Jinan on September 16,2008.